In vitro and in vivo effects of kisspeptin antagonists p234, p271, p354, and p356 on GPR54 activation.
Kisspeptins (KPs) and their receptor (GPR54 or KiSS1R) play a key-role in regulation of the hypothalamic-pituitary-gonadal axis and are therefore Miscellaneous interesting targets for therapeutic interventions in the field of reproductive endocrinology.As dogs show a rapid and robust LH response after the administration of KP10, they can serve as a